Our CMAs
- Suitable for advanced histologic analyses, such as immunohistochemistry (IHC) and in situ hybridization (ISH).
- Applications include:
- Assay optimization
- Daily quality control
- Inter-laboratory comparisons
- Proficiency Testing
- Produced from cell pellets supplied by clients or trusted industry partners.
- Built with standard core diameters of 1.0mm, 1.5mm, 2.0mm and depths up to 15mm.
- Custom cores sizes and cell densities are available upon request.
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FOR RESEARCH USE ONLY
Customizable
Customize with number of cores, core diameter and depth, or cell density.
Built with cell cultures provided by you or carefully selected from trusted sources.
Certified
CMA blocks are quality checked by a board-certified pathologist.
All cell culture identities in a CMA block are recorded and mapped in our custom database for maximum traceability.
High Yield
Our blocks are built to be highly uniform in cell density, and as tall as desired.
With careful technique, the blocks can yield up to 100-150 sections per 1mm (cut at 3-4 microns) so you can get the best price per section.
Our CMA Products

Breast 3-Core Control
Catalog Number: BC-3-1-3-1
This control spans 0-3+ HER2 expression levels. Other markers covered by this control include ER, PR, GATA3, GCDFP-15, Mammaglobin, Keratin 7, Keratin 20, CDX2 and others. The array slides may be helpful for initial assay optimization, validation, and daily QC for monitoring assay consistency.

Her2Low 7-Core Control (with Tissue*)
Catalog Number: BC-7-1-3-2-B
This control spans 0-3+ expression levels with special emphasis on the Low-HER2 range with an optional HER2+ tissue. The array slides may be helpful for initial assay optimization, validation, and daily QC for monitoring assay consistency.

Mismatch Repair Control
Catalog Number: MMR-4-1-3-1
This control provides specific knockouts of each of the four proteins typically assessed when investigating mismatch repair enzyme deficiency: MLH1, MSH2, MSH6 and PMS2.
These cell lines provide appropriate assay positive and negative controls, as opposed to typical normal tissue controls that show no loss of protein expression.
The array slides may be helpful for initial assay optimization, validation, and daily QC for monitoring assay consistency.

Ki-67 4-Core Standardization Array
Catalog Number: Ki67-4-1-3-1-B
This array provides four cell lines with consistent proliferation indices that can help assess the sensitivity of Ki-67 assays. It is designed for use with the Visiopharm Qualitopix™ platform but may also be used with manual interpretation or other image analysis applications. The array slides may be helpful for initial assay optimization, validation, and daily QC for monitoring assay consistency.

Ki-67 6-Core Standardization Array
Catalog Number: Ki67-6-1-3-1-B
This array provides cell line mixes with consistent proliferation indices that can help assess the sensitivity and reproducibility of Ki-67 assays. The cell mixes consist of highly proliferative Jurkat cells titered into a background of negative cells (Sf9) at known concentrations. The product may be used with manual interpretation or image analysis applications. The array slides may be helpful for initial assay optimization, validation, and daily QC for monitoring assay consistency.

PD-L1 Standardization Array
Catalog Number: PD-L1-4-1-3-1
Four engineered cell lines with increasing levels of PD-L1 expression (and a wild-type negative parental line) are present in this array and can distinguish sensitivity among multiple PD-L1 assays. This control can help optimize a given assay and monitor drift of sensitivity over time. It can also be useful for intra-day, inter-day, inter-instrument, and inter-operator evaluation.

Multiple Biomarker Array
Catalog Number: MBA-8-1-3-1
This cell culture control array consistsof 8 tumor cell lines, including colon, prostate, breast, as well as B- and T-cell lymphoma. This arraycan serve as a control for a wide range of antibody targets and may be helpful in assay optimization, validation, and daily QC for monitoring assay consistency. This control array is suitable for IHC, FISH, and RNA-ISH.

P53 Cell Line Control
Catalog Number: P53-3-1-3-1-B (Block), P53-3-1-3-1-S (Slides)
This 3-core control consists of a p53 null mutant (T-cell lyphoma), a p53 wild type (thyroid carinoma) and a p53 missense mutant (prostate carcinoma).

Melanoma/BRAF V600E
Catalog Number:
This control contains a melanoma cell line that shows the BRAF V600E mutation. As such, it also may serve as a control for multiple melanocytic markers, such as S-100, Melan A, HMB45, SOX10, and PRAME, among others. The negative core is a thyroid medullary carcinoma with reactivity for TTF-1, calcitonin, synaptophysin, and villin, among others. A sensitivity control, showing 0%, 3%, 30%, and 100% BRAF V600E-containing cores is sold separately.

Kappa/Lambda for IHC and RNA in situ hybridization
Catalog Number: KL-3-1-3-1-B (Block), KL-3-1-3-1-S (Slides)
This control block is appropriate for use with immunohistochemical and RNA in situ hybridization (RNA-ISH) detection of Kappa and Lambda Immunoglobulin Light Chains, among others. The negative control is a T-ALL and can serve as a control for TdT.

H. pylori
Catalog Number:
For more information and customization options, please contact us.
